Molecular inhibition gets cells on the move

Osaka University researchers revealed that two molecules, PTEN and PIP3, mutually inhibit each other to ensure their exclusive distribution at opposite ends of motile cells. This polarized distribution results in the establishment of pseudopodia only at one cell end, providing the driving force for cell movement. Although discovered in a simple organism, the slime mold, this mechanism may also be active in many more advanced species, including in mammalian immune cells.

Molecular inhibition gets cells on the move

Researchers at Osaka University show how the mutual inhibition of two molecules results in their localization at opposite ends of cells, acting as a trigger for the formation of appendages at ...

Thu 8 Nov 18 from Phys.org

Molecular inhibition gets cells on the move, Thu 8 Nov 18 from Eurekalert

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