Elegant antibody nanoparticles override immunological tolerance of tumors

An antibody is an agent of the immune system that attaches to an antigen. Usually antibodies recognize antigens on a virus or bacteria and attach to the invader to mark it for destruction by other immune cells. In a new study,  University of Colorado Anschutz researchers engineered an antibody to recognize and attach to a protein called EGFR. Bladder tumors (but not healthy cells) are often covered in EGFR. Other researchers have hooked molecules of chemotherapy to antibodies that recognize EGFR and have used this antibody-antigen system to micro-target the delivery of chemotherapy. In this case, researchers used nifty chemistry to attach gold nanoparticles to antibodies.read more

Elegant antibody nanoparticles override immunological tolerance of tumors

Immune checkpoint blockade (ICB) therapy using the antibody that combats the programmed cell death ligand 1 (PD-L1) shows great potential and is causing a revolution in clinical cancer management. ...

Fri 12 Jul 19 from Medical Xpress

Elegant antibody nanoparticles override immunological tolerance of tumors, Fri 12 Jul 19 from Eurekalert

Frying Cancer With Vibrating Gold Nanoparticles

An antibody is an agent of the immune system that attaches to an antigen. Usually antibodies recognize antigens on a virus or bacteria and attach to the invader to mark it for destruction by ...

Wed 10 Jul 19 from Science 2.0

Tightening the tumor-targeting abilities of checkpoint blockade immunotherapy

(American Association for the Advancement of Science) Seeking to improve upon existing checkpoint inhibitor therapies, scientists have developed a common checkpoint inhibitor (anti-PD-L1) in ...

Fri 12 Jul 19 from Eurekalert

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