New method to identify intermediates in protein folding

Insight may help the development of methods to treat diseases at the nanoscale Enabling bioengineers to design new molecular machines for nanotechnology applications is one of the possible outcomes of a study by University of Montreal researchers that was published in Nature Structural and Molecular Biology today. The scientists have developed a new approach to visualize how proteins assemble, which may also significantly aid our understanding of diseases such as Alzheimer's and Parkinson's, which are caused by errors in assembly. "In order to survive, all creatures, from bacteria to humans, monitor and transform their environments using small protein nanomachines made of thousands of atoms," explained the senior author of the study, Prof. Stephen Michnick of the university's department of biochemistry. "For example, in our sinuses, there are complex receptor proteins that are activated in the presence of different odor molecules. Some of those scents warn us of danger; others tell us that food is nearby."

New method to identify intermediates in protein folding

Tryptophan residues introduced at various positions in a protein chain identify folding intermediates that are too short-lived to be structurally characterized otherwise.

Tue 12 Jun 12 from Nanodot

Scientists watch proteins self-assemble

Enabling bioengineers to design new molecular machines for nanotechnology applications is one of the possible outcomes of a study by University of Montreal researchers that was published in ...

Sun 10 Jun 12 from Phys.org

Tiny Living Machines Self-assemble

Insight may help the development of methods to treat diseases at the nanoscale Enabling bioengineers to design new molecular machines for nanotechnology applications is one of the possible ...

Tue 12 Jun 12 from RedOrbit

Tiny Living Machines Self-assemble, Mon 11 Jun 12 from RedOrbit

Research Offers Potential to Develop Nanoscale Treatment for Diseases

By Gary Thomas Researchers at the University of Montreal have developed a method to visualize the assembly of proteins that would pave the way for bioengineers to design molecular scale devices ...

Mon 11 Jun 12 from AZoNano

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