Blue light allows for making carbon-nitrogen bonds without 'energetically unfavorable' reactions

Amines, molecules containing carbon-nitrogen (CN) bonds, are among the most common and biologically important molecules in organic chemistry; 84% of small-molecule pharmaceuticals contain at least one CN bond (1). Hydroamination, the direct addition of an NH bond across a carbon-carbon double or triple bond, represents an ideal approach for the synthesis of amines (2). Despite extensive research over the past several decades, the efficient and direct intermolecular hydroamination of unactivated alkenes with anti-Markovnikov regio-selectivity (see the top panel of the figure) has remained a challenge. On page 727 of this issue, Musacchio et al. (3) report a photochemical strategy for creating reactive ammonium radical cations (ARCs) that can form these less stable isomers. Authors: Travis L. Buchanan, Kami L. Hull

[Perspective] Illuminating amination

Thu 16 Feb 17 from Science Now

New amination chemistry brought to light

Photogenerated radical cations yield amines previously impossible to make

Thu 16 Feb 17 from CandEN

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