Simple single-step N-terminal modification of proteins

Proteins are widely used in medicine, biology and chemistry. Enhancing their inherent properties by adding functional molecules to their structures is a common and important step in many fields. For example, adding fluorescent molecules allows proteins to be traced and quantified. Many modification strategies with various advantages have been described. Osaka University researchers now report a simple N terminus-specific modification carried out under mild conditions using new reagents prepared in one step. Their findings were published online in ChemBioChem.

Simple single-step N-terminal modification of proteins

Proteins are widely used in medicine, biology and chemistry. Enhancing their inherent properties by adding functional molecules to their structures is a common and important step in many fields. ...

Thu 13 Feb 20 from Phys.org

Simple N-terminal modification of proteins

(Osaka University) Osaka University researchers report efficient one-step modification of protein N termini using functional molecules containing 1H-1,2,3-triazole-4-carbaldehyde (TA4C) groups. ...

Thu 13 Feb 20 from Eurekalert

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