Mechanism of controlling autophagy by liquid-liquid phase separation revealed

Autophagy is a mechanism through which cellular protein is degraded. Selective autophagy had been thought to prevent the onset of diseases, but the state of proteins in which they could be efficiently degraded had been unclear. A team of Japanese scientists have discovered that autophagy is effective for selectively degrading protein in a state of liquid droplet that is formed through liquid-liquid phase separation but does poorly with the degradation of protein in aggregation.

Mechanism of controlling autophagy by liquid-liquid phase separation revealed

Under JST's Strategic Basic Research Programs, Noda Nobuo (Laboratory Head) and Fujioka Yuko (Senior Researcher) of the Institute of Microbial Chemistry, in collaboration with other researchers, ...

Fri 14 Feb 20 from Phys.org

Mechanism of controlling autophagy by liquid-liquid phase separation revealed, Fri 14 Feb 20 from Eurekalert

Autophagy degrades liquid droplets—but not aggregates—of proteins

Under JST's Strategic Basic Research Programs, Noda Nobuo and Yamasaki Akinori at the Institute of Microbial Chemistry, in collaboration with other researchers, have discovered that autophagy ...

Thu 13 Feb 20 from Phys.org

Autophagy degrades liquid droplets, but not aggregates, of proteins

Autophagy is a mechanism through which cellular protein is degraded. Selective autophagy had been thought to prevent the onset of diseases, but the state of proteins in which they could be efficiently ...

Thu 13 Feb 20 from Eurekalert

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